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Uncertainty, Variability, and Sensitivity Analyses in Simulation Models

Research output: Chapter in Book/Report/Conference proceedingChapter

Original languageEnglish (US)
Title of host publicationQuantitative Modeling in Toxicology
PublisherJohn Wiley and Sons
Pages429-458
Number of pages30
ISBN (Print)9780470998090
DOIs
StatePublished - Mar 30 2010

All Science Journal Classification (ASJC) codes

  • General Pharmacology, Toxicology and Pharmaceutics
  • General Biochemistry, Genetics and Molecular Biology

Keywords

  • ADMET (absorption, distribution, metabolism, excretion and toxicity) - and different toxicants
  • Data/parametric uncertainties and variability propagation - guidelines conducting uncertainty and variability analyses
  • Fuzzy Theory, uncertainty analysis of systems - vagueness or "fuzziness" in system attributes
  • Model uncertainties and its impact on output metrics - through several methods
  • Natural uncertainty and variability
  • No truly "global" method - characterizing sensitivities and uncertainties
  • Sensitivity Analysis (SA) - quantitative study of sensitivity
  • Simulation models, convenient and essential approximations - estimating quantities that cannot be directly measured
  • Tiered approach for uncertainty analysis of simulation models
  • Uncertainty, variability and sensitivity analyses in simulation models

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