Mavacamten inhibits myosin activity by stabilizing the myosin interacting-heads motif and stalling motor force generation

Keyphrases

• Stall 100%
• Myosin 100%
• Force Generation 100%
• Mavacamten 100%
• Myosin Interacting-heads Motif 100%
• Motor Domain 33%
• Interacting Heads Motif 33%
• Therapeutic Potential 16%
• Sudden Cardiac Death 16%
• Disease Progression 16%
• Mass Spectrometry Analysis 16%
• Primed State 16%
• Cardiac Myosin 16%
• Actin Binding 16%
• Invasive Procedures 16%
• Symptom Relief 16%
• Hypertrophic Cardiomyopathy 16%
• Bound States 16%
• Small Molecule Modulators 16%
• Inorganic Phosphate 16%
• Binding Cleft 16%
• Heavy Meromyosin 16%
• Adenosine Diphosphate 16%
• Cross-linking Mass Spectrometry 16%
• Cryo-electron Microscopy Structure 16%
• Diastolic Relaxation 16%
• Generation Cycles 16%
• First Foods 16%
• Young People 16%
• Motor Dynamics 16%
• Promising Therapeutics 16%
• Global Resolution 16%
• Cleft Closure 16%
• Heart muscle Disease 16%
• Quantitative Cross-linking 16%

Biochemistry, Genetics and Molecular Biology

• Myosin 100%
• Adenosine Diphosphate 50%
• Small Molecule 25%
• Genetics 25%
• Actin 25%
• Cross-Link 25%
• Sudden Cardiac Death 25%
• Heavy Meromyosin 25%
• Cryoelectron Microscopy 25%