Interaction Between Innate Lymphoid Cells and the Nervous System

Yuanyue Zhang; Rachel Grazda; Qi Yang

doi:10.1007/978-981-16-8387-9_9

Interaction Between Innate Lymphoid Cells and the Nervous System

Yuanyue Zhang
, Rachel Grazda
, Qi Yang

Research output: Chapter in Book/Report/Conference proceeding › Chapter

4 Scopus citations

Abstract

The interaction between the immune system and the nervous system remains an intriguing enigma. Recent studies indicate that innate lymphoid cells (ILCs), a unique family of innate effector cells, participate in intense cross talk with the nervous system. In the mucosal barrier sites, ILCs have been found to co-localize with neurons, nerves, glial cell projectors, and neuroendocrine cells. The cross talk between ILCs and peripheral nervous system orchestrates mucosal homeostasis and immunity. In addition, the barrier tissues of the central nervous system (CNS) also provide conductive microenvironment for ILC development and maintenance. Activities of CNS-associated ILCs impact the outcome of various CNS disorders. In this chapter, we review and discuss the intricate and bidirectional interaction between ILCs and nervous system.

Original language	English (US)
Title of host publication	Advances in Experimental Medicine and Biology
Publisher	Springer
Pages	135-148
Number of pages	14
DOIs	https://doi.org/10.1007/978-981-16-8387-9_9
State	Published - 2022
Externally published	Yes

Publication series

Name	Advances in Experimental Medicine and Biology
Volume	1365
ISSN (Print)	0065-2598
ISSN (Electronic)	2214-8019

All Science Journal Classification (ASJC) codes

General Biochemistry, Genetics and Molecular Biology

Keywords

Choroid plexus
Innate lymphoid cells
Meningeal immunity
Neuroimmunology
The enteric nervous system

Access to Document

10.1007/978-981-16-8387-9_9

Cite this

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title = "Interaction Between Innate Lymphoid Cells and the Nervous System",

abstract = "The interaction between the immune system and the nervous system remains an intriguing enigma. Recent studies indicate that innate lymphoid cells (ILCs), a unique family of innate effector cells, participate in intense cross talk with the nervous system. In the mucosal barrier sites, ILCs have been found to co-localize with neurons, nerves, glial cell projectors, and neuroendocrine cells. The cross talk between ILCs and peripheral nervous system orchestrates mucosal homeostasis and immunity. In addition, the barrier tissues of the central nervous system (CNS) also provide conductive microenvironment for ILC development and maintenance. Activities of CNS-associated ILCs impact the outcome of various CNS disorders. In this chapter, we review and discuss the intricate and bidirectional interaction between ILCs and nervous system.",

keywords = "Choroid plexus, Innate lymphoid cells, Meningeal immunity, Neuroimmunology, The enteric nervous system",

author = "Yuanyue Zhang and Rachel Grazda and Qi Yang",

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language = "English (US)",

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AU - Zhang, Yuanyue

AU - Grazda, Rachel

AU - Yang, Qi

PY - 2022

Y1 - 2022

N2 - The interaction between the immune system and the nervous system remains an intriguing enigma. Recent studies indicate that innate lymphoid cells (ILCs), a unique family of innate effector cells, participate in intense cross talk with the nervous system. In the mucosal barrier sites, ILCs have been found to co-localize with neurons, nerves, glial cell projectors, and neuroendocrine cells. The cross talk between ILCs and peripheral nervous system orchestrates mucosal homeostasis and immunity. In addition, the barrier tissues of the central nervous system (CNS) also provide conductive microenvironment for ILC development and maintenance. Activities of CNS-associated ILCs impact the outcome of various CNS disorders. In this chapter, we review and discuss the intricate and bidirectional interaction between ILCs and nervous system.

AB - The interaction between the immune system and the nervous system remains an intriguing enigma. Recent studies indicate that innate lymphoid cells (ILCs), a unique family of innate effector cells, participate in intense cross talk with the nervous system. In the mucosal barrier sites, ILCs have been found to co-localize with neurons, nerves, glial cell projectors, and neuroendocrine cells. The cross talk between ILCs and peripheral nervous system orchestrates mucosal homeostasis and immunity. In addition, the barrier tissues of the central nervous system (CNS) also provide conductive microenvironment for ILC development and maintenance. Activities of CNS-associated ILCs impact the outcome of various CNS disorders. In this chapter, we review and discuss the intricate and bidirectional interaction between ILCs and nervous system.

KW - Choroid plexus

KW - Innate lymphoid cells

KW - Meningeal immunity

KW - Neuroimmunology

KW - The enteric nervous system

UR - https://www.scopus.com/pages/publications/85130042770

UR - https://www.scopus.com/pages/publications/85130042770#tab=citedBy

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DO - 10.1007/978-981-16-8387-9_9

M3 - Chapter

C2 - 35567745

AN - SCOPUS:85130042770

T3 - Advances in Experimental Medicine and Biology

SP - 135

EP - 148

BT - Advances in Experimental Medicine and Biology

PB - Springer

ER -

Interaction Between Innate Lymphoid Cells and the Nervous System

Abstract

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All Science Journal Classification (ASJC) codes

Keywords

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