HIV infection is associated with diffusing capacity impairment in women

Meghan E. Fitzpatrick; Matthew R. Gingo; Cathy Kessinger; Lorrie Lucht; Eric Kleerup; Ruth M. Greenblatt; David Claman; Claudia Ponath; Serena Fong; Laurence Huang; Alison Morris

doi:10.1097/QAI.0b013e3182a9213a

HIV infection is associated with diffusing capacity impairment in women

Meghan E. Fitzpatrick
, Matthew R. Gingo
, Cathy Kessinger
, Lorrie Lucht
, Eric Kleerup
, Ruth M. Greenblatt
, David Claman
, Claudia Ponath
, Serena Fong
, Laurence Huang
, Alison Morris

Research output: Contribution to journal › Article › peer-review

47 Scopus citations

Abstract

Respiratory dysfunction is common with HIV infection, but few studies have directly assessed whether HIV remains an independent risk factor for pulmonary function abnormalities in the antiretroviral therapy era. Additionally, few studies have focused on pulmonary outcomes in HIV+ women. We tested associations between risk factors for respiratory dysfunction and pulmonary outcomes in 63 HIV+ and 36 HIV-uninfected women enrolled in the Women's Interagency HIV Study. Diffusing capacity (DL_CO) was significantly lower in HIV+ women (65.5% predicted vs. 72.7% predicted, P = 0.01), and self-reported dyspnea in HIV+ participants was associated with both DL_CO impairment and airflow obstruction. Providers should be aware that DL_CO impairment is common in HIV infection, and that either DL_CO impairment or airflow obstruction may cause respiratory symptoms in this population.

Original language	English (US)
Pages (from-to)	284-288
Number of pages	5
Journal	Journal of Acquired Immune Deficiency Syndromes (1999)
Volume	64
Issue number	3
DOIs	https://doi.org/10.1097/QAI.0b013e3182a9213a
State	Published - Nov 1 2013
Externally published	Yes

All Science Journal Classification (ASJC) codes

Infectious Diseases
Pharmacology (medical)

Keywords

AIDS
chronic
hepatitis C
HIV
pulmonary diffusing capacity
pulmonary function

Access to Document

10.1097/QAI.0b013e3182a9213a

Cite this

@article{373360c5b57448798af49c231739c33b,

title = "HIV infection is associated with diffusing capacity impairment in women",

abstract = "Respiratory dysfunction is common with HIV infection, but few studies have directly assessed whether HIV remains an independent risk factor for pulmonary function abnormalities in the antiretroviral therapy era. Additionally, few studies have focused on pulmonary outcomes in HIV+ women. We tested associations between risk factors for respiratory dysfunction and pulmonary outcomes in 63 HIV+ and 36 HIV-uninfected women enrolled in the Women's Interagency HIV Study. Diffusing capacity (DLCO) was significantly lower in HIV+ women (65.5\% predicted vs. 72.7\% predicted, P = 0.01), and self-reported dyspnea in HIV+ participants was associated with both DLCO impairment and airflow obstruction. Providers should be aware that DLCO impairment is common in HIV infection, and that either DLCO impairment or airflow obstruction may cause respiratory symptoms in this population.",

keywords = "AIDS, chronic, hepatitis C, HIV, pulmonary diffusing capacity, pulmonary function",

author = "Fitzpatrick, \{Meghan E.\} and Gingo, \{Matthew R.\} and Cathy Kessinger and Lorrie Lucht and Eric Kleerup and Greenblatt, \{Ruth M.\} and David Claman and Claudia Ponath and Serena Fong and Laurence Huang and Alison Morris",

year = "2013",

month = nov,

day = "1",

doi = "10.1097/QAI.0b013e3182a9213a",

language = "English (US)",

volume = "64",

pages = "284--288",

journal = "Journal of Acquired Immune Deficiency Syndromes (1999)",

issn = "1525-4135",

publisher = "Wolters Kluwer Health",

number = "3",

}

TY - JOUR

T1 - HIV infection is associated with diffusing capacity impairment in women

AU - Fitzpatrick, Meghan E.

AU - Gingo, Matthew R.

AU - Kessinger, Cathy

AU - Lucht, Lorrie

AU - Kleerup, Eric

AU - Greenblatt, Ruth M.

AU - Claman, David

AU - Ponath, Claudia

AU - Fong, Serena

AU - Huang, Laurence

AU - Morris, Alison

PY - 2013/11/1

Y1 - 2013/11/1

N2 - Respiratory dysfunction is common with HIV infection, but few studies have directly assessed whether HIV remains an independent risk factor for pulmonary function abnormalities in the antiretroviral therapy era. Additionally, few studies have focused on pulmonary outcomes in HIV+ women. We tested associations between risk factors for respiratory dysfunction and pulmonary outcomes in 63 HIV+ and 36 HIV-uninfected women enrolled in the Women's Interagency HIV Study. Diffusing capacity (DLCO) was significantly lower in HIV+ women (65.5% predicted vs. 72.7% predicted, P = 0.01), and self-reported dyspnea in HIV+ participants was associated with both DLCO impairment and airflow obstruction. Providers should be aware that DLCO impairment is common in HIV infection, and that either DLCO impairment or airflow obstruction may cause respiratory symptoms in this population.

AB - Respiratory dysfunction is common with HIV infection, but few studies have directly assessed whether HIV remains an independent risk factor for pulmonary function abnormalities in the antiretroviral therapy era. Additionally, few studies have focused on pulmonary outcomes in HIV+ women. We tested associations between risk factors for respiratory dysfunction and pulmonary outcomes in 63 HIV+ and 36 HIV-uninfected women enrolled in the Women's Interagency HIV Study. Diffusing capacity (DLCO) was significantly lower in HIV+ women (65.5% predicted vs. 72.7% predicted, P = 0.01), and self-reported dyspnea in HIV+ participants was associated with both DLCO impairment and airflow obstruction. Providers should be aware that DLCO impairment is common in HIV infection, and that either DLCO impairment or airflow obstruction may cause respiratory symptoms in this population.

KW - AIDS

KW - chronic

KW - hepatitis C

KW - HIV

KW - pulmonary diffusing capacity

KW - pulmonary function

UR - https://www.scopus.com/pages/publications/84886444181

UR - https://www.scopus.com/pages/publications/84886444181#tab=citedBy

U2 - 10.1097/QAI.0b013e3182a9213a

DO - 10.1097/QAI.0b013e3182a9213a

M3 - Article

C2 - 23979000

AN - SCOPUS:84886444181

SN - 1525-4135

VL - 64

SP - 284

EP - 288

JO - Journal of Acquired Immune Deficiency Syndromes (1999)

JF - Journal of Acquired Immune Deficiency Syndromes (1999)

IS - 3

ER -

HIV infection is associated with diffusing capacity impairment in women

Abstract

All Science Journal Classification (ASJC) codes

Keywords

Access to Document

Other files and links

Fingerprint

Cite this