Abstract
In addition to hyperresponsiveness in asthma, airway smooth muscle (ASM) also manifests an inflammatory phenotype characterized by augmented expression of mediators that enhance inflammation, contribute to tissue remodelling and augment leucocyte trafficking and activity. Our present review summarizes contemporary understanding of ASM-derived mediators and their paracrine and autocrine actions in airway diseases.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 68-80 |
| Number of pages | 13 |
| Journal | British Journal of Pharmacology |
| Volume | 163 |
| Issue number | 1 |
| DOIs | |
| State | Published - May 2011 |
| Externally published | Yes |
All Science Journal Classification (ASJC) codes
- Pharmacology
Keywords
- COPD
- airway inflammation
- airway obstruction
- airway remodelling
- cytokines
- non-canonical pathways
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