Antiseizure medications

Side Effects of Drugs Annual is an annual publication including the most recently published adverse effects and toxicities associated with medications. The antiseizure medication (ASM) chapter is a review of literature published between January 2023 and December 2023. The literature review included the ASMs clobazam, clonazepam, diazepam, primidone, tiagabine, vigabatrin, gabapentin, pregabalin, valproic acid, carbamazepine, cenobamate, eslicarbazepine acetate, lacosamide, lamotrigine, oxcarbazepine, phenytoin, zonisamide, perampanel, topiramate, brivaracetam, cannabidiol, ethosuximide, ezogabine, felbamate, fenfluramine, levetiracetam, rufinamide, and stiripentol. Articles with new information were prioritized. Notable themes published in 2023 included hyperammonemic encephalopathy with valproic acid, severe cutaneous adverse drug reactions with carbamazepine, hepatotoxicity, interactions with cannabidiol, and teratogenicity with ASMs.