Project Details
Description
DESCRIPTION: Despite a long list of organ systems adversely affected by aging in HIV, the lung remains relatively understudied, and combined effects of aging and HIV on the lung are unknown. Development of chronic obstructive pulmonary disease (COPD) may be accelerated in HIV despite antiretroviral treatment (ART). Average age of HIV+ individuals with COPD in our cohorts is 51 years compared to 61 years in our HIV- controls (p600 HIV+ and HIV- participants with thorough physiologic characterization and biological samples. The proposal will fill the gap in knowledge of pulmonary effects of physiologic and cellular aging in HIV and is directly responsive to PA-12-175 (Multidisciplinary Studies of HIV/AIDS and Aging). Results will enhance understanding of pulmonary aging and translate into improvements in prevention and management of HIV pulmonary disease.
| Status | Finished |
|---|---|
| Effective start/end date | 9/4/13 → 6/30/19 |
Funding
- National Heart, Lung, and Blood Institute: $662,017.00
- National Heart, Lung, and Blood Institute: $686,609.00
- National Heart, Lung, and Blood Institute: $681,884.00
- National Heart, Lung, and Blood Institute: $678,491.00
- National Heart, Lung, and Blood Institute: $676,488.00
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